Aging of the organism is associated with highly reproducible DNA methylation (DNAm) changes, which facilitate estimation of donor age. Cancer is also associated with DNAm changes, which may contribute to disease development. Here, we speculate that age‐associated DNAm changes may increase the risk of tumor initiation. Notably, when using epigenetic signatures for age‐estimations tumor cells are often predicted to be much older than the chronological age of the patient. We demonstrate that aberrant hypermethylation within the gene DNA methyltransferase 3A (DNMT3A) (...) – which may contribute to initiation of acute myeloid leukemia (AML) – is particularly observed in AML samples that reveal significantly more age‐associated DNAm changes. The functional relevance of age‐associated DNAm changes remains to be elucidated, but they occur genome wide, in a highly reproducible manner, and most likely influence chromatin organization – and hence may favor acquisition of aberrant DNAm patterns contributing to cancer in the elderly. (shrink)

Social enterprises, like almost all organizations, continuously strive for external legitimacy. To be perceived as externally legitimated by society, social enterprises often engage in strategic partnerships. However, scholars have only recently turned their attention to the legitimating function of such partnerships. The purpose of this article is to address the hitherto neglected construct of inter-partner legitimacy. Drawing on institutional theory, we hypothesize that such inter-partner legitimacy affects the resource transfer among partners, which will, in turn, be recognized by society and (...) will subsequently affect each partner’s external legitimacy. Dyadic data of 121 strategic partnerships between social enterprises and their key partners confirm our hypotheses. We add to institutional theory by integrating the often ignored dimension of inter-partner legitimacy into our analysis and demonstrate its relevance to each partner’s external legitimacy and to resource transfer. Further contributions to the literature on institutional theory, legitimacy, social entrepreneurship, and inter-organizational relationships are identified. (shrink)

The purpose of this article is to discuss narration of ethical themes in nursing care. The text represents part of the findings of an ethnographic study aimed at description of everyday work on an oncology ward. Nurses on this ward are constantly involved in ethical care issues and narratives are told to share experiences. Of vital importance in ethical decision making is the perpetual creation of a mediating moral world constituted by daily experience. The need for making space in nursing (...) for a continual learning conversation is expressed and in this I include writings of nursing theorists. (shrink)

According to Alexius Meinong, in order to give a philosophical explanation of the world we need to consider both existent and nonexistent objects, lest we fall into the "prejudice in favour of the real". The paper starts by examining some basic concepts of object theory seen as an existence-free science (modes of being, principle of independence of so-being from being, "Aussersein" and Meinong's paradox). There follows an exposition of Bertrand Russell's position, characterized by a "robust sense of reality", and afterwards (...) an analysis of differences and similarities between the two philosophers. The paper ends with a short account of Meinongian semantics and a comparison between object theory and metaphysics. (shrink)

This essay deals with some philosophical problems concerning the understanding of ethical conceptions in an alien culture. Its aim is to show that in investigating such conceptions we cannot proceed on purely empirical grounds; our own ethical concepts will, in a conceptual sense, determine what it is conceivable that we find.

What happens us emotionally when we read a work of fiction? According to some philosophers our emotional engagement with fiction gives rise to a paradox and involves either irrationality or participation in a game of make believe. I argue that an Object Theory in a meinongian style, by supporting a realistic perspective on fictional emotions, is able to dissolve the paradox of fiction by providing a positive ontological account of fictional entities (and the properties characterizing them).

This essay is a critical discussion of Dipesh Chakrabarty’s book Provincializing Europe as well as a first sketch of a History on Equal Terms. After giving a short summary of Provincializing Europe, I first argue, against Chakrabarty, that there is no necessary connection between the discipline of history and the metanarratives of modernity. To the contrary: the founding idea of the discipline of history was a turn against such grand narratives. With his attempt to deconstruct the narratives of the European (...) Enlightenment and of modernity, Chakrabarty therefore has to be regarded as a thinker of radical historicism rather than as a critic of the discipline of history. Second, I criticize the use of the term “modernity” in Provincializing Europe and the concept of modernity in general. Instead of a deconstruction of the discipline of history, I propose a deconstruction of the concept of modernity. This could open up the way for a History on Equal Terms situated within the discipline of history, that is, a historiography that would—just as Chakrabarty rightly demands—in principle pay the same attention to and expect relevant results from any region in the world, depending only on the focus of research. (shrink)

“Naturalismo” è una parola che si dice in molti modi, almeno tanti quanti nella storia della filosofia e nel sentire comune sono i modi in cui si è parlato di “natura” e di espressioni simili. Oggi, il tema del naturalismo in filosofia e della cosiddetta naturalizzazione che una filosofia dovrebbe eventualmente attrezzare determinate nozioni e teorie è tornato prepotentemente alla ribalta della riflessione filosofica, sulla scia dei successi provenienti dalle scienze cognitive (linguistica, n...

Nel 1856 Madame Bovary esce a puntate sulla «Revue de Paris» (1° ottobre - 15 dicembre), per comparire poi in versione integrale un anno dopo – in seguito all’assoluzione di Gustave Flaubert, avvenuta il 7 febbraio – presso l’editore Lévy. Il titolo dell’opera, molto semplice, è decisamente in linea con il realismo: l’autore si mette da parte, rinunciando alla propria voce e alla propria opinione, per fare parlare direttamente i personaggi e gli eventi che li riguardano. Infatti il titolo non...

“Naturalismo” è una parola che si dice in molti modi, almeno tanti quanti nella storia della filosofia e nel sentire comune sono i modi in cui si è parlato di “natura” e di espressioni simili. Oggi, il tema del naturalismo in filosofia e della cosiddetta naturalizzazione che una filosofia dovrebbe eventualmente attrezzare determinate nozioni e teorie è tornato prepotentemente alla ribalta della riflessione filosofica, sulla scia dei successi provenienti dalle scienze cognitive (linguistica, n...

Il cosiddetto “paradosso della finzione” nasce dal tentativo di spiegare quale tipo di emozioni proviamo verso quegli oggetti che troviamo nei romanzi e nei film e che sappiamo perfettamente essere fittizi. Si tratta di un paradosso classico, tornato alla ribalta nel 1975 dopo la pubblicazione di un articolo di Colin Radford che partiva precisamente dall’interrogativo riguardante le lacrime che versiamo per ciò che non è reale (come un personaggio fittizio, appunto). Perché ci commuoviamo per il suicidio di Anna Karenina se (...) sappiamo che non esiste? Che differenza c’è tra piangere per Anna Karenina, piangere per una bugia, piangere per la depressione e fare finta di piangere perché si vuol fare credere a chi ci guarda che siamo sinceramente commossi? In Piangere e ridere davvero (2009) Maurizio Ferraris offre un’interessante proposta teorica per dissolvere il paradosso in questione e si sofferma su alcune distinzioni fondamentali riguardanti le nostre reazioni emotive a stimoli reali e fittizi. In questo saggio si prende spunto dalla teoria di Ferraris e ci si propone di chiarire che cosa significhi fare finta di rispondere emotivamente a qualcosa nella vita di tutti i giorni e quale sia la differenza tra queste “finte” emozioni e quelle che invece proviamo durante la fruizione di opere che sappiamo essere di finzione. Saranno scelti come esempi paradigmatici il caso Fenaroli (al centro della cronaca italiana alla fine degli anni Cinquanta), Il vedovo di Dino Risi e Scusate il ritardo di Massimo Troisi. (shrink)

According to Paolo D’Angelo my Philosophy of Literature actually is an Analytical Philosophy of Literature. His main worry does not concern simply the title, but the fact of my having consciously excluded some authors just because, he maintains, they are not analytic philosophers. In this note I try to explain my reasons together with a defense of philosophy of literature in its own peculiarity distinguishing it from literary criticism, literature in philosophy and philosophy as literature.

The anti-fascist cantata Il canto sospeso, the string quartet Fragmente - Stille, an Diotima and the 'Tragedy of Listening' Prometeo cemented Luigi Nono's place in music history. In this study, Carola Nielinger-Vakil examines these major works in the context of Nono's amalgamation of avant-garde composition with Communist political engagement. Part I discusses Il canto sospeso in the context of all of Nono's anti-fascist pieces, from the unfinished Fučik project to Ricorda cosa ti hanno fatto in Auschwitz. Nielinger-Vakil explores Nono's (...) position at the Darmstadt Music Courses, the evolution of his compositional technique, his penchant for music theatre and his use of spatial and electronic techniques to set the composer and his works against the diverging circumstances in Italy and Germany after 1945. Part II further examines these concerns and shows how they live on in Nono's work after 1975, culminating in a thorough analysis of Prometeo. (shrink)

Este artículo sintetiza algunos aspectos del proyecto “Hierro y bronce. Criterios para la valoración y conservación de la herrería artística en el patrimonio arquitectónico del Uruguay”[i], cuyo objetivo es establecer los atributos patrimoniales de los elementos ornamentales metálicos asociados a fachadas del patrimonio arquitectónico nacional y contribuir a su difusión, puesta en valor y conservación. A lo largo de la investigación se abordan los aspectos socioculturales, artísticos, formales, técnicos y, por último, los relativos al deterioro de estos elementos y las (...) pautas para su preservación y restauración. La metodología se basa en el estudio de fuentes primarias, éditas e inéditas, en la revisión de bibliografía especializada y en el trabajo de campo sobre una muestra representativa de elementos ornamentales metálicos aplicados a las fachadas de la arquitectura montevideana. Fue relevado un total de 250 edificios, correspondientes a los distintos períodos que distinguimos en la evolución de la herrería local entre finales del siglo XVIII y mediados del siglo XX. Se trata de un aporte inicial que profundiza en un campo escasamente abordado en nuestro medio acerca del conocimiento y difusión de los trabajos de herrería en el marco del patrimonio arquitectónico y artístico uruguayo, proporcionando información útil a la academia, las instituciones vinculadas a la valoración y conservación patrimonial y el público general. Notas [i] Proyecto concursado y financiado en la modalidad Investigación y Desarrollo (I+D), Comisión Sectorial de Investigación científica (CSIC), Universidad de la República, a realizarse entre marzo de 2018 y marzo de 2020, por un equipo interdisciplinario integrado por docentes e investigadores de las facultades de Arquitectura, Diseño y Urbanismo: Miriam Hojman, Valentina Marchese y Tatiana Rimbaud (Instituto de Historia), Gianella Mussio, Leticia Olivera, Carola Romay y Verónica Ulfe (Instituto de Tecnologías); de la Facultad de Humanidades y Ciencias de la Educación: Ernesto Beretta (Instituto de Ciencias Históricas-Historia del Arte); y de la Facultad de Ingeniería: Sofía Aguiar (Instituto de Ensayo de Materiales). El presente artículo fue elaborado por todos los integrantes del equipo. (shrink)

Durante la edad escolar, los sujetos van logrando una madurez sintáctica, evidenciada en el incremento de lacomplejidad estructural de los textos que producen. Diversas teorías han dado cuenta de dicha complejidad(Hunt, 1970; Katzenberger, 2004; Nir & Berman, 2010), sosteniendo que la misma está vinculada con eltipo de relaciones interclausulares dentro del texto. Asimismo, corroboran que dicha complejidad no sólo seincrementa con el nivel educativo, sino también está guiada por la modalidad discursiva. A partir de estapropuesta, el proyecto FONDECYT 1100600, se (...) planteó el objetivo de describir el desarrollo de la sintaxisoral, considerando otra perspectiva de la complejidad: la diversidad interclausular. Para ello, se aplicarondos tareas de elicitación (narración y explicación), a 250 estudiantes de kinder, 3º y 6º básico, Iº y IVº mediode Valparaíso y Santiago. Luego de ser transcritos y analizados, se reconocieron en los textos las relacionesinterclausulares y se estableció un índice de diversidad clausular, en el entendido de que a medida que seusaban más formas para relacionar las cláusulas, mayor sería la complejidad sintáctica de los mismos. Losresultados muestran un incremento de la diversidad clausular a medida que aumenta el nivel educativo, sinembargo, su significatividad se da sólo entre algunos niveles. Además, entre ambos tipos de textos no semanifiestan grandes diferencias, salvo en Kínder y en IVº Medio. Estos hallazgos permiten vislumbrar que lamadurez sintáctica implica tener mayor cantidad de estructuras gramaticales y utilizarlas estratégicamentepara construir un determinado texto. (shrink)

A decade in the making, the _Handbook i_s the definitive contemporary exposition of interpersonal psychoanalysis. It provides an authoritative overview of development, psychopathology, and treatment as conceptualized from the interpersonal viewpoint.

L’approccio analitico alla letteratura è stato spesso «strumentale». Di frequente, è stata solo un pretesto per riflettere su questioni filosofiche che la trascendono: i filosofi del linguaggio, ad esempio, l’hanno utilizzata per indagare le differenze tra il linguaggio scientifico (dotato di valore di verità) e quello finalizzato al godimento estetico; gli esperti di ontologia si sono interrogati sulla natura delle entità finzionali. Nel suo libro, Carola Barbero mette in discussione questo...

Cultural Intersections in Later Chinese Buddhism. Edited by Marsha Weidner. University of Hawai'i Press, Honolulu 2001. ix, 234 pp. US$44.00. ISBN 0-8248-2308-7.

This response to Carola Dietze’s critique of Provincializing Europe takes up for examination three key expressions or ideas on which the original argument of the book was founded: hyperreal Europe, historicism, and political modernity. I appreciate the spirit of Dietze’s engagement with the book, but I show that her critique is based on a degree of misapprehension of these three central ideas. While clarifying the details and the degree of my disagreement with Dietze, I provide my own critique of (...) Dietze’s proposal of “equal histories” by arguing that Dietze has not named or explained the unit with respect to which different histories could be considered equal. I also argue that Dietze’s proposals about judging societies only by their “own” standards, and basing human dignity on the idea of a “human nature” that could be seen as a “constant,” do not solve the problems she sees with my book and are themselves open to some serious historical and logical criticism. (shrink)

This Element provides an introduction to the hiddenness argument, as presented by John Schellenberg, and its up-to-date discussion in a comprehensible way. It concludes with a brief assessment of where things stand, from the author's point of view, and why divine hiddenness should not reduce a reflective theist's confidence in theism.

The paper analyzes Christmas Eve, a short dialogue by the protestant romantic Friedrich Schleiermacher published in 1806, as an attempt to translate the traditional language of Christmas into the idiom of the modern, gendered family life. The central message of Christmas is rearticulated in the realm of private family life, the division of gender, the naïve happiness of the children etc. At the same time, the form of the dialogue among the family members and some close friends is used to (...) raise different interpretations of Christmas, including moments of suffering and national identity. The text thus both reflects and actively shapes a shifting interpretation of religious traditions in the modern word precisely by enacting the translation of Christian language into a modern vernacular (that of family, intimacy, nation) as an ongoing process among the different partners of the dialogue. (shrink)

The so-called Kulturkampf, the conflict between the German Reich and the Catholic Church in the 1870s and 1880s, is one of the most important ideological conflicts of the late nineteenth century and reveals a political theological dynamic characteristic of the modern (German) nation state. This paper analyzes the paradoxes of this conflict along the lines with Eric Santner’s analysis of political representations. During the Kulturkampf, Catholic citizens were publicly suspected of not being loyal Germans, and the Catholic Church is widely (...) figured as an (inner) enemy in the liberal press and in modern caricatures. In these polemics, numerous political theological figures emerge: images of a gendered relation of domination of the (female) church by the (male) state, phantasies of the body politic and its precarious unity as well as of its purification respectively of the extermination of its others that continue to determine other ideological conflicts in the twentieth century. (shrink)

This article examines the widespread diagnosis of a »crisis of rhetoric« around 1800 from the hitherto largely neglected perspective of the sermon. Four exemplary cases are used to show how rhetoric continues and transforms itself. Franz Theremin reaffirms the function of rhetoric and represents the largely unbroken continuity of rhetorical knowledge in 19th century homiletics and preaching practice. Johann G. Fichte develops the format of a philosophical sermon supposed to serve precisely as a propaedeutic of critical philosophy, which is in (...) itself anti-rhetorical. Friedrich D.E. Schleiermacher develops a new conception of the sermon and also a highly influential conception of religion from the problem of the communicability of religious knowledge. Karl P. Moritz proclaims a religion of art in the form of a sermon and narrates the comical failure of this proclamation, thus exposing the very limits of a sacralization of art. Through these four case studies we can gain a more precise understanding of the »crisis of rhetoric« and envision an interdisciplinary research on the sermon in which literary studies and theology would cooperate closely. (shrink)

ABSTRACTHow accurate are insights compared to analytical solutions? In four experiments, we investigated how participants' solving strategies influenced their solution accuracies across different types of problems, including one that was linguistic, one that was visual and two that were mixed visual-linguistic. In each experiment, participants' self-judged insight solutions were, on average, more accurate than their analytic ones. We hypothesised that insight solutions have superior accuracy because they emerge into consciousness in an all-or-nothing fashion when the unconscious solving process is complete, (...) whereas analytic solutions can be guesses based on conscious, prematurely terminated, processing. This hypothesis is supported by the finding that participants' analytic solutions included relatively more incorrect responses than timeouts compared to their insight responses. (shrink)

'Lebendiges Judentum', schreibt Walter Benjamin 1930 an Gershom Scholem, 'habe ich in durchaus keiner anderen Gestalt kennengelernt als in dir.' Scholem, Historiker der Kabbala, früher Zionist, scharfer Kritiker der jüdischen Assimilation, Freund und Herausgeber Benjamins ist eine schillernde Gestalt und Autor faszinierender Texte. Die in den letzten Jahren veröffentlichten Jugendtagebücher und -briefe geben Einsicht in die Entwicklung des jungen Scholem und die Werkstatt seines Schreibens. Nach heftigen persönlichen Krisen und vehementen Auseinandersetzungen mit seinen Mitzionisten lernt Scholem, 'im Namen' des Judentums (...) zu sprechen. Er eignet sich die jüdische Überlieferung an und entwirft eine Philosophie und Theologie des 'Kommentars'. Als Historiker der Kabbala macht Scholem die verschlossene Welt mystischer Texte durch eine dynamische Lektüre zum Kraftfeld jüdischer Identität. Der Band führt einen jungen Intellektuellen auf der Suche nach sich und dem Judentum vor, er untersucht die Verflechtung von politischen, theologischen und wissenschaftlichen Schriften und leuchtet deren intellektual-geschichtliche Kontexte aus. (shrink)

Name der Zeitschrift: Naharaim Jahrgang: 10 Heft: 1 Seiten: 103-126.

Kant's relation to religion and theology is complex since he tries both to delimit theology's influence and to inherit its discursive power. The essay explores the different critical strategies and rhetorical means that Kant uses to deal with theology: theological analogies and metaphors in his systematic thought, a new kind of,philosophy of religion,' a political theology of civil society, and finally a specific way of reading the Bible.

Von Max Weber stammt die Formulierung von der „Entzauberung der Welt“, die bis heute unser Selbstverständnis prägt: die Art, wie wir uns, unser Verhältnis zu unserer Vergangenheit und auch zu anderen vorstellen. Wir leben in der Moderne, und das heißt für uns: in einer Welt, die keinen Zauber mehr kennt. ‚Welt‘ ist für uns geradezu der Inbegriff einer eindimensionalen Wirklichkeit, andere Welten können wir uns kaum noch vorstellen, jedenfalls haben wir keine Begriffe mehr von ihnen, sondern können allenfalls in Metaphern (...) und Geschichten von ihnen sprechen. Nun ist ‚Entzauberung‘ genau so eine Metapher, die nicht nur in sich mehrdeutig ist – ist das ein aktiver oder passiver Prozess, ist er zu bewerten oder zu beklagen? –, sondern auch Teil einer spezifischen literarischen Gattungstradition: der Elegie. Denn wenn bei Weber die Beschreibung der entzauberten Welt schnell in eine Allegorie des Götterkampfes übergeht – in der modernen, pluralistischen Welt erheben sich die alten Götter wieder und beginnen ihren ewigen Kampf –, so verweist das auch auf die Tradition der Elegie: der geschichtsphilosophischen Elegie bei Schiller und ihren Variationen und Umschriften bei Hölderlin und Heine. Der Durchgang durch diese Rezeptionsgeschichte zeigt nicht nur, dass die Rede von der „entzauberten Welt“ selbst einen hochgradig literarischen Charakter hat, sondern dass auch der Literatur selbst – hier eben: der Elegie, die Verlorenes beklagt – ein zentraler Platz in dieser Geschichte angewiesen wird. Ein Platz, der freilich selber nicht stabil ist, sondern nur in der Arbeit an der Figur, der konstanten Neu- und Umbesetzung umkreist werden kann. (shrink)